5-Amino 1MQ
$55.99
5-Amino-1MQ is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor supplied for research on NAD⁺ metabolism, methyl donor utilization, and energy regulation. It is not a peptide and is intended solely as a biochemical probe.
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Research Overview
5-Amino-1-methylquinolinium (5-Amino-1MQ) selectively targets NNMT, an enzyme linking nicotinamide clearance with S-adenosylmethionine-dependent methylation. [1,2] Inhibition of NNMT by 5-Amino-1MQ allows researchers to explore how altered nicotinamide flux influences NAD⁺ pools, sirtuin activity, epigenetic marks, and metabolic adaptation in cell and animal models. [2-4]
Molecular Target & Enzyme Inhibition
Structural features of 5-Amino-1MQ support active-site binding and competition with NNMT substrates. [1,2] Enzymology assays quantify IC₅₀ values, binding kinetics, and downstream metabolite changes.
Metabolic Pathways & Energy Homeostasis
Oncology & Systems Biology Models
NNMT overexpression in tumors and other tissues positions 5-Amino-1MQ as a tool for dissecting links between methylation balance, NAD⁺-dependent enzymes, and cellular proliferation, aiding target validation efforts.
Product Usage:
This product is meant only for research use. It is made for lab testing and in vitro experiments (outside a living body), not for use in people or animals. All information on this website is for learning purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. It should only be used by trained professionals in a proper lab setting. This product is not a medicine, food, or cosmetic, and must not be sold or used as one.